FWIW, I remove my camper several times a year. Reasons you might want to include:
1. you need to haul something other than the camper (lumber, etc);
2. you need the truck serviced but the garage you use either doesn't have a door high enough or a lift strong enough to lift the combined weight (this happens more often than you think;
3. you need the camper left someplace to have it serviced.
Now I have helped several people load and unload their flatbed campers that were bolted directly through the floor. I have no doubt its strong but lining up 4-6 bolts when the camper is suspended in the air is like eating soup in the rain -- sure, it can be done but why?
When I had my Bundutec Odyssey built and loaded on my Alumline flatbed, I wanted an external option. My flat bed has rub rails and we drilled holes in those rails in the front and in the flatbed frame in the rear and use Fastguns attached to the jack plates to secure the camper on. I also added an aluminum side plate so the camper would not shift sideways.
In 80,000 plus miles and lots of it off road and off camber, the camper has never moved and the holes have not enlarged at all. And its very easy to remove.
I've attached a picture for reference -- just another way to consider.
Hope this helps.