As close as it is too Reno, I would suggest making a drive down there on a weekend BEFORE you move.
If I was going to move there, I would spend a day or two driving around the entire Fresno area checking out the good areas and the bad.
It would not be my first choice to be moving there (I can sure think of nicer areas to be).
If I HAD to go, I would personally be looking for a small place outside of town.
Just like any big city, there will be good parts of town and some bad parts of town i'm sure.
Good luck on whatever you decide.
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